منابع مشابه
Experimental toxicology in silico.
A review on applicability of in silico methods for toxicity testing by calculation for regulatory purposes, their survey and background of QSAR (Quantitative Structure-Activity Relationships) analysis are presented.
متن کاملIn Silico Toxicology – Non-Testing Methods
In silico toxicology in its broadest sense means "anything that we can do with a computer in toxicology." Many different types of in silico methods have been developed to characterize and predict toxic outcomes in humans and environment. The term non-testing methods denote grouping approaches, structure-activity relationship, and expert systems. These methods are already used for regulatory pur...
متن کاملToxicology is IN: in silico, in vitro, integrated testing strategy.
for hazard identification and characterization and/or safety assessment of chemicals based on multiple information sources, which integrates and weighs all relevant existing data, guiding the targeted generation of new data to inform regulatory decision-making about potential hazards or risks. Such an approach has already been successfully applied in the ECVAM Skin Sensitisation Project and has...
متن کاملFood for thought ... on in silico methods in toxicology.
this series of articles has already addressed in vitro and in vivo tools (Hartung, 2007; Hartung, 2008b). With this contribution addressing computational toxicology we now try to complete considerations on the main methodological approaches in toxicology. However, we do still plan to address specific aspects, such as endpoints (omics, image technologies), high-throughput testing or physiology-b...
متن کاملIn silico approaches to predicting drug metabolism, toxicology and beyond.
The discovery and optimization of new drug candidates is becoming increasingly reliant upon the combination of experimental and computational approaches related to drug metabolism, toxicology and general biopharmaceutical properties. With the considerable output of high-throughput assays for cytochrome-P450-mediated drug-drug interactions, metabolic stability and assays for toxicology, we have ...
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ژورنال
عنوان ژورنال: Regulatory Toxicology and Pharmacology
سال: 2019
ISSN: 0273-2300
DOI: 10.1016/j.yrtph.2019.104403